Experiments on the treatment of animals infected with trypanosomes, by means of atoxyl, vaccines, cold, X-Rays, and leucocytic extract; enumerative methods employed. (preliminary note.)

These experiments were conducted with funds given by Sir Edwin During-Lawrence, Bart., for the purpose of testing the effect of cold on disease, and were suggested by Major R. Ross as a part of the studies made in connection with a case of Sleeping Sickness reported upon in an accompanying paper by him and Dr. David Thomson. Although many researches have been made on the effect of atoxyl and other drugs, we believe that these are the first in which that effect has been measured by regular daily counts of the parasites by measured thick film methods. I. Atoxyl. From a study of the patient W. A. at the Royal Southern Hospital by Major R. Ross and D. Thomson, it will be noted that atoxyl failed to be of any marked benefit to the patient, and in the doses administered there was no noticeable trypanocidal action. Various doses of atoxyl are recommended in treatment of human trypanosomiasis, and the patient (W. A.) received 4 grains as a maximum dose. It was impossible in this case to push the drug further, as the patient quickly showed signs of the toxic action of the drug.