Preclinical study demonstrates programmable stress-hormone sensing in Escherichia coli Nissle, highlighting new design strategies for living medicines.
Pathogens sense host stress hormones in the gut and use them to regulate motility and virulence. A new study in PLOS Biology transfers this pathway to Escherichia coli Nissle and redesigns its regulation to drive programmable outputs.
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Weston R. Whitaker (2026) studied this question.
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