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August 29, 2026Food FrontiersOpen Access

Lacticaseibacillus rhamnosus LRPerfectus158 Alleviates Postinfectious Irritable Bowel Syndrome in Mice and Is Associated With Modulation of Hypothalamic–Pituitary–Adrenal Axis Activity

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Authors

DSDun SuYGYajuan GuoYWYue Wang

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Overview

Animal study demonstrates that Lacticaseibacillus rhamnosus relieves postinfectious irritable bowel syndrome in mice, indicating therapeutic potential via gut barrier and stress axis modulation.

Key Points

  • To examine whether Lacticaseibacillus rhamnosus LRPerfectus158 alleviates postinfectious irritable bowel syndrome and to clarify its gut-barrier and neuroendocrine mechanisms.
  • Established a postinfectious irritable bowel syndrome mouse model via Citrobacter rodentium infection combined with water-avoidance stress.
  • Administered L. rhamnosus LRPerfectus158 and assessed visceral hypersensitivity, anxiety-like behaviors, colon length, fecal moisture, and serum corticosterone levels.
  • Evaluated intestinal barrier integrity and inflammation via colonic transcriptomics, histology, and fecal metagenomic sequencing.
  • LRPerfectus158 administration significantly reduced fecal moisture, restored colon length, attenuated visceral hypersensitivity, and relieved anxiety-like behaviors in mice.
  • Treatment decreased serum corticosterone levels, attenuated hippocampal injury, suppressed mucosal inflammation, and upregulated the epithelial barrier markers ZO-1 and MUC2.
  • Metagenomic sequencing revealed altered gut microbiota composition, including increased relative abundances of Muribaculum, Duncaniella, Bacteroides uniformis, and Ligilactobacillus murinus.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/6a92995f8e5d7d1fc0c113b7https://doi.org/10.1002/fft2.70353
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