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August 29, 2026Journal of NeuroInterventional Surgery

Millipede Aspiration for Revascularization in Stroke (MARRS): prospective trial of a novel 0.088 inch corrugated catheter

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Authors

RNRaul G. NogueiraMRManuel RequenaJDJaydevsinh Dolia

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Overview

Prospective single-arm trial demonstrates high revascularization rates with a corrugated aspiration catheter in acute ischemic stroke, highlighting effective large vessel occlusion treatment.

Key Points

  • To evaluate the safety and revascularization efficacy of the corrugated Millipede catheter system in patients presenting with acute ischemic stroke due to large vessel occlusion.
  • Prospective, multicenter, single-arm interventional trial (NCT05714501) enrolling 180 patients aged 18–85 years across sites in the US (57%) and Europe (43%) within 8 hours of stroke onset.
  • Eligible patients had internal carotid artery, M1, M2, or basilar artery occlusions treated with either Millipede88 or Millipede70 catheters based on target vessel caliber.
  • Primary efficacy endpoint was modified Thrombolysis in Cerebral Infarction (mTICI) ≥2b achieved in ≤3 passes without rescue therapy, with core lab adjudication.
  • Primary endpoint of mTICI ≥2b within ≤3 passes was met in 88.9% (160/180 patients; 95% CI lower bound 84.3%) in the intention-to-treat population.
  • Millipede88 achieved 96% navigation success, a 60% first-pass mTICI ≥2c rate (increasing to 75% in M1 occlusions), and an 85% final mTICI ≥2c revascularization rate.
  • Safety outcomes showed symptomatic intracranial hemorrhage in 2.3%, intracranial dissection in 1.1%, no vessel perforations, and a 90-day all-cause mortality rate of 13.9%.

Cite This Study

Nogueira et al. (2026) studied this question.

synapsesocial.com/papers/6a9299958e5d7d1fc0c11a93https://doi.org/10.1136/jnis-2026-025573
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