Comparative genomic study reveals lineage-specific gene remodeling and root-biased berberine metabolism in Berberis wilsoniae, highlighting specialized alkaloid evolution in medicinal plants.
The first chromosome-scale genome of Berberis wilsoniae provides a valuable resource for understanding the evolution and chromosomal organization of benzylisoquinoline alkaloid-related genes. Integrated comparative genomics, alkaloid profiling, and transcriptomic analyses reveal lineage-specific remodeling of BIA-related genes and highlight root-biased berberine-related metabolism in this medicinal species. These findings establish a basis for future studies of specialized metabolism and evolutionary genomics in Berberidaceae and Ranunculales.
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Feng et al. (2026) studied this question.
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