Pediatric Case of Non‐Islet Cell Tumor Hypoglycemia Driven by Hepatoblastoma: The Diagnostic Approach and Impact of Chemotherapy on Big IGF‐II

Q: What does this research mean for the field?

Hepatoblastoma can drive non-islet cell tumor hypoglycemia in pediatric patients, and chemotherapy impacts the associated Big IGF-II levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kuniaki Tanaka; Mototsugu Nagao; Izumi Fukuda; Atsushi Iwai; Kenichiro Kobayashi; Tatsuya Okamoto; Shinya Okamoto; Shohei Azumi; Itaru Kato; Katsutsugu Umeda; Junko Takita; Ikuya Usami

doi:10.1002/1545-5017.70655

August 27, 2026Pediatric Blood & Cancer

Pediatric Case of Non‐Islet Cell Tumor Hypoglycemia Driven by Hepatoblastoma: The Diagnostic Approach and Impact of Chemotherapy on Big IGF‐II

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Key Points

To describe the diagnostic approach for pediatric non-islet cell tumor hypoglycemia driven by hepatoblastoma and evaluate the impact of chemotherapy on circulating big IGF-II levels.
Clinical, biochemical, and radiological evaluation of a pediatric patient presenting with severe non-islet cell tumor hypoglycemia.
Serial monitoring of tumor response and circulating levels of high-molecular-weight insulin-like growth factor II (big IGF-II) before and during chemotherapy.
Systemic chemotherapy induced tumor regression and suppressed aberrant big IGF-II secretion.
Reduction in circulating big IGF-II correlated directly with the resolution of recurrent, refractory hypoglycemia.

Implication

Case report reveals resolution of hypoglycemia and reduction of big IGF-II following chemotherapy in pediatric hepatoblastoma, highlighting targeted endocrine diagnostic strategies.

Abstract

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Cite This Study

Tanaka et al. (2026) studied this question.

synapsesocial.com/papers/6a9299bb8e5d7d1fc0c11cdb https://doi.org/10.1002/1545-5017.70655

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Pediatric Case of Non‐Islet Cell Tumor Hypoglycemia Driven by Hepatoblastoma: The Diagnostic Approach and Impact of Chemotherapy on Big IGF‐II

Key Points

Implication

Abstract

Discussion

Cite This Study

Pediatric Case of Non‐Islet Cell Tumor Hypoglycemia Driven by Hepatoblastoma: The Diagnostic Approach and Impact of Chemotherapy on Big IGF‐II

Key Points

Implication

Abstract

Discussion

Cite This Study

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