First‐Recorded Alcohol Use Disorder Diagnosis as an Ascertainment Outcome: Implications for GLP ‐1 Target Trial Emulations

Chien‐Huei Sung; Lien‐Chung Wei

doi:10.1002/pds.70472

August 27, 2026Pharmacoepidemiology and Drug Safety

First‐Recorded Alcohol Use Disorder Diagnosis as an Ascertainment Outcome: Implications for GLP ‐1 Target Trial Emulations

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Key Points

To examine the methodological and clinical validity of using first-recorded alcohol use disorder diagnoses as an outcome in observational target trial emulations studying glucagon-like peptide-1 receptor agonists.
Conceptual and methodological analysis of target trial emulation design principles applied to pharmacoepidemiologic datasets.
Evaluation of electronic health record phenotyping and outcome ascertainment strategies without generating or analyzing primary empirical datasets.
Identifies substantial risks of outcome misclassification and ascertainment bias when relying solely on initial diagnostic billing codes for alcohol use disorder.
Highlights how unmeasured past alcohol exposure and delayed diagnosis timing can distort causal effect estimates in GLP-1 trial emulations.

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Implication

Methodological perspective uncovers challenges in using first-recorded alcohol use disorder diagnoses during GLP-1 target trial emulations, highlighting risks of outcome ascertainment bias.

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Sung et al. (2026) studied this question.

synapsesocial.com/papers/6a9299db8e5d7d1fc0c1213e https://doi.org/10.1002/pds.70472

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First‐Recorded Alcohol Use Disorder Diagnosis as an Ascertainment Outcome: Implications for GLP ‐1 Target Trial Emulations

Key Points

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Implication

Abstract

Discussion

Cite This Study

First‐Recorded Alcohol Use Disorder Diagnosis as an Ascertainment Outcome: Implications for GLP ‐1 Target Trial Emulations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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