What question did this study set out to answer?

Characterize a newly identified red cell antibody and define the corresponding high-frequency public antigenic determinant, Gya (Gregory).

July 8, 1967Transfusion

A New Public Antigenic Determinant Gya (Gregory)

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Authors

JSJane L. SwansonBristol-Myers Squibb (Sweden)MZMary ZweberMemorial Blood Centers HPHerbert F. PoleskyUniversity of Minnesota

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Implication

Familial serological investigation reveals a novel public blood group antigen Gya in two sisters, indicating rare homozygous inheritance stimulated by pregnancy.

Key Points

Characterize a newly identified red cell antibody and define the corresponding high-frequency public antigenic determinant, Gya (Gregory).
Serological evaluation of serum and red blood cells obtained from two sisters born to consanguineous parents.
Immunoglobulin class determination and clinical history assessment to identify the mechanism of antibody stimulation.
Identified a previously unrecognized public red cell antigenic determinant designated Gya (Gregory).
Characterized anti-Gya as an IgG antibody that developed following stimulation during pregnancy.
Established that Gy(a—) individuals are homozygous for a rare Gy allele inherited from a shared ancestral lineage.

Cite This Study

Swanson et al. (1967) studied this question.

synapsesocial.com/papers/6a929a7cfa60aefc093abe7b https://doi.org/10.1111/j.1537-2995.1967.tb05522.x

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Implication

Familial serological investigation reveals a novel public blood group antigen Gya in two sisters, indicating rare homozygous inheritance stimulated by pregnancy.

A New Public Antigenic Determinant Gya (Gregory)

Discussion

Member takes

Implication

Key Points

Cite This Study

A New Public Antigenic Determinant Gya (Gregory)

Discussion

Member takes

Implication

Key Points

Cite This Study

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