SUMMARY.— The guinea‐pig was used as a model for the analysis of flare and rash reactions observed after intravenous injections of DNBSO3 Na in animals with a contact allergy to dinitrochlorbenzene. Histological and pharmacological studies could not confirm the mechanism of an Arthus type of reaction. It is suggested that in addition to allergic mechanisms non‐specific and non‐allergic phenomena may also play a role in provoking the clinical symptoms of flare and rash in hypersensitive animals.
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Jansen et al. (1970) studied this question.
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