Sensorineural hearing loss in survivors of neonatal extracorporeal membrane oxygenation

The follow-up information of sensorineural hearing loss (SNHL) in neonatal extracorporeal membrane oxygenation (ECMO) survivors was reviewed by Medline search (1985-1996) using indexing terms; ECMO, follow-up outcome. Only seven reports (from six different centres) provide information on the results of audiologic assessment in 371 ECMO survivors with follow-up duration of 1-10 years. SNHL is a significant neurologic morbidity in neonatal ECMO survivors with a reported frequency of 3-21% (average 7.5%, 28 of 371). From three of the seven reports that provide information of clinical features in the survivors with SNHL, SNHL is often an isolated disability (16 of 19, 84%) and the loss is usually bilateral involving high frequencies. SNHL can be late-onset (7 of 19, 37% diagnosed after infancy) and progressive. Multicentre prospective studies with regular comprehensive audiologic assessment until bilateral thresholds can be obtained are urgently required to define the course of SNHL. Basic research is needed to evaluate the role of various factors (e.g., peroxynitrite and free radicals) in the pathogenesis of SNHL. The information generated will help to develop preventive measures and cost-effective management of these ECMO survivors.