Answers are grounded in this paper and cite their sources.
BJU InternationalVolume 96, Issue 9 p. 1333-1338 Neurophysiology of the ejaculatory process: developing perspectives Ion G. Motofei, Corresponding Author Ion G. Motofei St. Pantelimon Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, andIon G. Motofei, Str. Tarnita, Nr. 14, Sect. 3, Bucharest, Romania. e-mail: [email protected]Search for more papers by this authorDavid L. Rowland, David L. Rowland Department of Psychology, Valparaiso University, Valparaiso, IN, USASearch for more papers by this author Ion G. Motofei, Corresponding Author Ion G. Motofei St. Pantelimon Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, andIon G. Motofei, Str. Tarnita, Nr. 14, Sect. 3, Bucharest, Romania. e-mail: [email protected]Search for more papers by this authorDavid L. Rowland, David L. Rowland Department of Psychology, Valparaiso University, Valparaiso, IN, USASearch for more papers by this author First published: 15 November 2005 https://doi.org/10.1111/j.1464-410X.2005.05850.xCitations: 39Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Masters WH, Johnson VE. Human sexual response. In Male Sexual Response. Boston: Little Brown, 1966: 73–80 Google Scholar 2 Kaplan HS. The New Sex Therapy. New York: Brunner/ Mazel, 1974 Google Scholar 3 Motofei IG, Rowland DL. The physiological basis of human sexual arousal: neuroendocrine sexual asymmetry. Int J Androl 2005; 28: 78–87 10.1111/j.1365-2605.2004.00514.x CASPubMedWeb of Science®Google Scholar 4 Anderson J. The role of antiandrogen monotherapy in the treatment of prostate cancer. BJU Int 2003; 91: 455–61 10.1046/j.1464-410X.2003.04026.x CASPubMedWeb of Science®Google Scholar 5 Heiman J, Rowland DL. Effects of instructions on affective and physiological response in sexually-dysfunctional and normal men. J Psychosom Res 1983; 27: 105–16 10.1016/0022-3999(83)90086-7 PubMedWeb of Science®Google Scholar 6 McMahon CG, Samali R. Pharmacological treatment of premature ejaculation. Curr Opin Urol 1999; 9: 553–61 10.1097/00042307-199911000-00011 CASPubMedGoogle Scholar 7 Kedia KR, Markland C. The ejaculatory process. In ES Hafez ed. Human Semen and Fertility Regulation in Men. St. Louis: CV Mosby, 1976: 497–503 Google Scholar 8 Metz ME, Pryor JL, Nesvacil LJ, Abuzzahab F, Koznar J. Premature ejaculation: a psychophysiological review. J Sex Marital Ther 1997; 23: 3–23 10.1080/00926239708404413 CASPubMedWeb of Science®Google Scholar 9 Argiolas A, Melis MR. The neurophysiology of the sexual cycle. J Endocrinol Invest 2003; 26 (Suppl. 3): 20–2 CASPubMedGoogle Scholar 10 Shafik A. The mechanism of ejaculation: the glans-vasal and urethromuscular reflexes. Arch Androl 1998; 41: 71–8 10.3109/01485019808987948 CASPubMedWeb of Science®Google Scholar 11 Rowland DL, Slob AK. Premature ejaculation: psychophysiological considerations in theory, research, and treatment. Annu Rev Sex Res 1997; 8: 224–53 CASPubMedGoogle Scholar 12 Thomas AJ Jr. Ejaculatory dysfunction. Fertil Steril 1983; 39: 445–54 10.1016/S0015-0282(16)46929-3 PubMedWeb of Science®Google Scholar 13 Bohlen D, Hugonnet CL, Mills RD, Weise ES, Schmid HP. Five meters of H2O: the pressure at the urinary bladder neck during human ejaculation. Prostate 2000; 44: 339–41 10.1002/1097-0045(20000901)44:4<339::AID-PROS12>3.0.CO;2-Z CASPubMedWeb of Science®Google Scholar 14 Simpson G, McCann B, Lowy M. Treatment of premature ejaculation after traumatic brain injury. Brain Inj 2003; 17: 723–9 10.1080/0269905031000110481 PubMedWeb of Science®Google Scholar 15 Kuhr CS, Heiman J, Cardenas D, Bradley W, Berger RE. Premature emission after spinal cord injury. J Urol 1995; 153: 429–31 10.1097/00005392-199502000-00045 PubMedWeb of Science®Google Scholar 16 McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 1998; 159: 1935–8 10.1016/S0022-5347(01)63201-4 CASPubMedWeb of Science®Google Scholar 17 Carro-Juarez M, Cruz SL, Rodriguez-Manzo G. Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation. Brain Res 2003; 975: 222–8 10.1016/S0006-8993(03)02686-6 CASPubMedWeb of Science®Google Scholar 18 Chung SK, McVary KT, McKenna KE. Sexual reflexes in male and female rats. Neurosci Lett 1988; 94: 343–8 10.1016/0304-3940(88)90042-0 PubMedWeb of Science®Google Scholar 19 McKenna KE, Chung SK, McVary KT. A model for the study of sexual function in anesthetized male and female rats. Am J Physiol 1991; 261: 1276–85 PubMedWeb of Science®Google Scholar 20 Gil L, Gomez LE, Duran I, Cueva-Rolon R. Muscarinic mediation of the urethrogenital reflex in spinal cord-transected rats. Pharmacol Biochem Behav 2000; 67: 215–23 10.1016/S0091-3057(00)00323-3 CASPubMedWeb of Science®Google Scholar 21 Yang CC, Bradley WE. Reflex innervation of the bulbocavernosus muscle. BJU Int 2000; 85: 857–63 10.1046/j.1464-410x.2000.00560.x CASPubMedWeb of Science®Google Scholar 22 Hansen MV, Ertekin C, Larsson LE. Cerebral evoked potentials after stimulation of the posterior urethra in man. Electroencephalogr Clin Neurophysiol 1990; 77: 52–8 10.1016/0168-5597(90)90016-7 CASPubMedWeb of Science®Google Scholar 23 Nordling J, Andersen JT, Walter S, Meyhoff HH, Hald T, Gammelgaard PA. Evoked response of the bulbocavernosus reflex. Eur Urol 1979; 5: 36–8 10.1159/000473058 CASPubMedWeb of Science®Google Scholar 24 Yeates WK. Ejaculation and its disorders. Arch Ital Urol Nefrol Androl 1990; 62: 137–48 CASPubMedGoogle Scholar 25 Shilon M, Paz GF, Homonnai ZT. The use of phenoxybenzamine treatment in premature ejaculation. Fertil Steril 1984; 42: 659–61 CASPubMedWeb of Science®Google Scholar 26 Rampin O, Giuliano F. Physiology and pharmacology of ejaculation. J Soc Biol 2004; 198: 231–6 CASPubMedGoogle Scholar 27 Yang CC, Bradley WE. Neuroanatomy of the penile portion of the human dorsal nerve of the penis. Br J Urol 1998; 82: 109–13 10.1046/j.1464-410x.1998.00669.x CASPubMedWeb of Science®Google Scholar 28 Yang CC, Bradley WE. Innervation of the human glans penis. J Urol 1999; 161: 97–102 10.1016/S0022-5347(01)62075-5 CASPubMedWeb of Science®Google Scholar 29 Yells DP, Hendricks SE, Prendergast MA. Lesions of the nucleus paragigantocellulas: effects on mating behavior in male rats. Brain Res 1992; 596: 73–9 10.1016/0006-8993(92)91534-L PubMedWeb of Science®Google Scholar 30 Liu YC, Salamone JD, Sachs BD. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behav Neurosci 1997; 111: 1361–7 10.1037/0735-7044.111.6.1361 CASPubMedWeb of Science®Google Scholar 31 Motofei IG. The etiology of premature ejaculation starting from a bihormonal model of normal sexual stimulation. Int J Impot Res 2001; 13: 49–50 10.1038/sj.ijir.3900632 CASPubMedWeb of Science®Google Scholar 32 Carmichael MS, Warburton VL, Dixen J, Davidson JM. Relationship among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav 1994; 23: 59–79 10.1007/BF01541618 CASPubMedWeb of Science®Google Scholar 33 Ackerman AE, Lange GM, Clemens LG. Effects of paraventricular lesions on sex behavior and seminal emission in male rats. Pharmacol Biochem Behav 1998; 60: 585–92 PubMedWeb of Science®Google Scholar 34 Masters WH, Johnson VE. Human Sexual Inadequacy. Boston: Little, Brown, 1970 Google Scholar 35 Meston CM, Frohlich PF. The neurobiology of sexual functions. Arch Gen Psychiatry 2000; 57: 1012–30 10.1001/archpsyc.57.11.1012 CASPubMedWeb of Science®Google Scholar 36 Williams W. Anesthetic ejaculation. J Sex Marital Ther 1985; 11: 19–29 10.1080/00926238508405955 PubMedWeb of Science®Google Scholar 37 Shen WW, Sata LS, Hofstatter L. Thioridazine and understanding sexual phases in both sexes. Psychiatr J Univ Ott 1984; 9: 187–90 CASPubMedWeb of Science®Google Scholar 38 Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002; 168: 2359–67 10.1016/S0022-5347(05)64146-8 PubMedWeb of Science®Google Scholar 39 Tagliamonte A, Tagliamonte P, Gessa GL, Brodie BB. Compulsive sexual activity induced by p-chlorophenylamine in normal and pinealectomized male rats. Science 1969; 166: 1433–5 10.1126/science.166.3911.1433 CASPubMedWeb of Science®Google Scholar 40 Kondo Y, Yamanouchi K. Potentiation of ejaculatory activity by median raphe nucleus lesions in male rats: effect of p-chlorophenylalanine. Endocr J 1997; 44: 873–9 10.1507/endocrj.44.873 CASPubMedWeb of Science®Google Scholar 41 Hillegaart V, Ahlenius S. Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181. Br J Pharmacol 1998; 125: 1733–43 10.1038/sj.bjp.0702239 CASPubMedWeb of Science®Google Scholar 42 Berendsen HH, Broekkamp CL. Behavioural evidence for functional interactions between 5-HT receptor sub-types in rats and mice. Br J Pharmacol 1990; 101: 667–73 10.1111/j.1476-5381.1990.tb14138.x CASPubMedWeb of Science®Google Scholar 43 Rehman J, Kaynan A, Christ G, Valcic M, Maayani S, Melman A. Modification of sexual behaviour of Long-Evans male rats by drugs acting on the 5 HT1a receptor. Brain Res 1999; 821: 414–25 10.1016/S0006-8993(98)01129-9 CASPubMedWeb of Science®Google Scholar 44 Hull EM, Bitran D, Pehek EA et al. Brain localization of cholinergic influence on male sex behavior in rats: agonists. Pharmacol Biochem Behav 1988; 31: 169–74 10.1016/0091-3057(88)90329-2 CASPubMedWeb of Science®Google Scholar 45 Waldinger MD, Hengeveld MW, Zwinderman AH. Ejaculation-retarding properties of paroxetine in patients with primary premature ejaculation: a double-blind, randomized, dose-response study. Br J Urol 1997; 79: 592–5 10.1046/j.1464-410X.1997.00102.x CASPubMedWeb of Science®Google Scholar 46 Courty E, Durif F, Zenut M, Courty P, Lavarenne J. Psychiatric and sexual disorders induced by apomorphine in Parkinson's disease. Clin Neuropharmacol 1997; 20: 140–7 10.1097/00002826-199704000-00005 CASPubMedWeb of Science®Google Scholar 47 Danjou P, Alexandre L, Warot D, Lacomblez L, Puech AJ. Assessment of erectogenic properties of apomorphine and yohimbine in man. Br J Clin Pharmacol 1988; 26: 733–9 10.1111/j.1365-2125.1988.tb05312.x CASPubMedWeb of Science®Google Scholar 48 Buckman MT, Kellner R. Reduction of distress in hyperprolactinemia with bromocriptine. Am J Psychiatry 1985; 142: 242–4 10.1176/ajp.142.2.242 CASPubMedWeb of Science®Google Scholar 49 Exton NG, Truong TC, Exton MS et al. Neuroendocrine response to film-induced sexual arousal in men and women. Psychoneuroendocrinology 2000; 25: 187–99 10.1016/S0306-4530(99)00049-9 CASPubMedWeb of Science®Google Scholar 50 Becker AJ, Uckert S, Stief CG et al. Cavernous and systemic plasma levels of norepinephrine and epinephrine during different penile conditions in healthy men and patients with erectile dysfunction. Urology 2002; 59: 281–6 10.1016/S0090-4295(01)01521-7 PubMedWeb of Science®Google Scholar 51 Creed KE, Carati CJ, Keogh EJ. The physiology of penile erection. Oxf Rev Reprod Biol 1991; 13: 73–95 CASPubMedWeb of Science®Google Scholar 52 Kim SC, Oh MM. Norepinephrine involvement in response to intracorporeal injection of papaverine in psychogenic impotence. J Urol 1992; 147: 1530–2 10.1016/S0022-5347(17)37617-6 PubMedWeb of Science®Google Scholar 53 Morales A, Condra M, Owen JA, Surridge DH, Fenemore J, Harris C. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol 1987; 137: 1168–72 10.1016/S0022-5347(17)44436-3 CASPubMedWeb of Science®Google Scholar 54 Price J, Grunhaus LJ. Treatment of clomipramine-induced anorgasmia with yohimbine: a case report. J Clin Psychiatry 1990; 51: 32–3 PubMedWeb of Science®Google Scholar 55 Vincent S, Robertson D. The broader view: catecholamine abnormalities. Clin Auton Res 2002; 12 (Suppl. 1): I44–9 10.1007/s102860200018 PubMedGoogle Scholar Citing Literature Volume96, Issue9December 2005Pages 1333-1338 ReferencesRelatedInformation
No takes yet. Share an insight, caveat, or question.
Motofei et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: