Key result
Intravenous naloxone did not clinically antagonize the inebriating effects of ethanol in healthy volunteers or alcohol-intoxicated out-patients.
Why the study?
Does naloxone improve ethanol-induced psychomotor impairment and clinical inebriation in healthy volunteers and alcohol-intoxicated patients?
Population
Healthy volunteers and alcohol-intoxicated out-patients
Comparison
Naloxone vs Placebo/saline
Design
RCT, double-blind
Authors
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Naloxone should not be used for ethanol intoxication; confirms ethanol effects are not opioid-mediated.
RCT (n=35)
Double-blind
Does naloxone improve ethanol-induced psychomotor impairment and clinical inebriation in healthy volunteers and alcohol-intoxicated patients?
Naloxone does not have clinical significance in antagonizing ethanol intoxication, suggesting inebriating effects of ethanol are not importantly mediated via central opioid mechanisms.
Nuotto et al. (1984) conducted an RCT in Alcohol intoxication (n=35). Naloxone vs. Placebo / Saline was evaluated on Ethanol-induced impairment of psychomotor performance and clinical inebriation. Intravenous naloxone did not clinically antagonize the inebriating effects of ethanol in healthy volunteers or alcohol-intoxicated out-patients.
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