June 1, 1998Critical Care Medicine
A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients
Why the study?
Does a positive rapid whole blood D-dimer assay predict vascular thrombosis, hospital mortality, and multiorgan dysfunction in adult patients admitted to a medical ICU?
Population
323 adult patients admitted to a medical intensive care unit at a university-affiliated teaching hospital.
Comparison
Positive rapid, semiquantitative assay for the… vs Negative SRDD assay.
Design
Cohort, blinded
Authors
Discussion
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Member takes
Implication
Positive SRDD assay may flag higher thrombosis and multiorgan dysfunction risk in ICU patients; prospective validation required before clinical adoption.
Structured PICO
Does a positive rapid whole blood D-dimer assay predict vascular thrombosis, hospital mortality, and multiorgan dysfunction in adult patients admitted to a medical ICU?
P
Population
323 adult patients admitted to a medical intensive care unit (ICU) at a university-affiliated teaching hospital.
I
Intervention
Positive rapid, semiquantitative assay for the detection of circulating D-dimer in whole blood (SRDD assay) within 24 hours of ICU admission.
C
Comparator
Negative SRDD assay.
O
Outcome
Vascular thrombosis, hospital mortality, and the development of multiorgan dysfunction.hard clinical
A rapid whole blood D-dimer assay upon ICU admission is independently associated with increased risks of vascular thrombosis, multiorgan dysfunction, and hospital mortality.
Cite This Study
Kollef et al. (1998) studied this question.