First total synthesis of murisolinElectronic Supplementary Information (ESI) available: characterization data of synthetic murisolin (1), and 1H and 13C NMR spectra of compounds 9, 12 and 1. See http://www.rsc.org/suppdata/cc/b3/b312362f/

The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydrofuranic aldehyde, which was also prepared via the asymmetric alkynylation.