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October 11, 2018Journal of Neurology Neurosurgery & Psychiatry

Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis

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Authors

FVFederico VerdeIRCCS Istituto Auxologico ItalianoPSPetra SteinackerLuther UniversityJWJochen H. WeishauptUniversity of Mannheim

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Verde et al. (2018) studied this question.

synapsesocial.com/papers/6a92a576363ee85fa149fcd9https://doi.org/10.1136/jnnp-2018-318704
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis2017 · 108 citations
  2. 2Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS2005 · 79 citations
  3. 3Diagnostic timelines and delays in diagnosing amyotrophic lateral sclerosis (ALS)2014 · 226 citations
  4. 4Characterization of Neuronal Intermediate Filament Protein Expression in Cervical Spinal Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis (ALS)2000 · 177 citations
  5. 5Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression2012 · 157 citations