Leukemia Chemotherapy and Centrilobular Hepatic Necrosis

Comments and Correction1 April 1977Leukemia Chemotherapy and Centrilobular Hepatic NecrosisJEFFREY S. WASSER, M.D., MORTON COLEMAN, M.D.JEFFREY S. WASSER, M.D.Search for more papers by this author, MORTON COLEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-508_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent issue (Ann Intern Med 85:578-582, 1976) Griner, Elbadawi, and Packman describe two patients who developed veno-occlusive disease of the liver after chemotherapy for acute leukemia. We wish to report the case of a patient with acute myelogenous leukemia, on similar chemotherapy, whose course was complicated by hepatic dysfunction and peliosis, a centrilobular hemorrhagic necrosis of the liver, considered by Griner and associates to be an early manifestation of veno-occlusive disease.A 20-year-old white woman with acute myelogenous leukemia was treated with a COAP regimen (cyclophosphamide, Oncovin®, arabinosyl cytosine, and prednisone). A partial remission followed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Hematology New York Hospital New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVascular Toxicity of Antineoplastic AgentsEarly Hepatic Nodular Hyperplasia and Submicroscopic Fibrosis Associated With 6-Thioguanine Therapy in Inflammatory Bowel DiseaseEarly Nodular Hyperplasia of the Liver Occurring With Inflammatory Bowel Diseases in Association With Thioguanine TherapyBudd-Chiari Syndrome: PathologyPeliosis hepatis induced by 6-thioguanine administration.12 Drug-induced vascular and sinusoidal lesions of the liverDo estrogens cause venocclusive disease of the liver?Hepatic veno-occlusive diseaseVeno-occlusive liver disease after dacarbazine therapy (DTIC) for melanomaVenocclusive Disease of the Liver after Bone Marrow Transplantation: Diagnosis, Incidence, and Predisposing FactorsHepatic and pancreatic damage produced by cytotoxic drugsAn analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantationHepatic veno-occlusive disease due to DTICHepatic failure in a patient treated with dacarbazine (DTIC) for malignant melanomaHepatic-Vein Thrombosis After Chemotherapy for HistiocytomaL. M. LEHRNER, PH.D., M.D., ROBERT E. ENCK, M.D. 1 April 1977Volume 86, Issue 4Page: 508-509KeywordsAcute myeloid leukemiaChemotherapyCyclophosphamideCytosineLiverLiver diseasesNecrosisPeliosis hepatis Issue Published: 1 April 1977 PDF downloadLoading ...