Key result
Under sustained low flow in dogs, there was significant rest redistribution of 99mTc-sestamibi (P<0.0001) and 201Tl (P=0.005) between early and late imaging relative to flow.
Why the study?
Does 99mTc-sestamibi demonstrate rest redistribution compared to early distribution in a canine model of low-flow ischemia?
Population
18 anesthetized, open-chest dogs with low-flow ischemia produced by partial occlusion of the left anterior…
Comparison
Intravenous injection of 99mTc-sestamibi, 201Tl… vs Evaluation at 20 minutes (early distribution)
Design
Preclinical
Follow-up
2.5 hours
Authors
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May support delayed viability imaging protocols; leaves open translation from canine low-flow models to patients.
Does 99mTc-sestamibi demonstrate rest redistribution compared to early distribution in a canine model of low-flow ischemia?
p-value: p=<.0001
In a canine model of low-flow ischemia, 99mTc-sestamibi showed detectable rest redistribution, suggesting that clinical imaging for myocardial viability should be delayed after resting injection.
Sinusas et al. (1994) studied Low-flow ischemia (n=18). 99mTc-sestamibi and 201Tl vs. Early (20 minutes) vs late (2.5 hours) imaging was evaluated on Myocardial 201Tl and 99mTc-sestamibi activities relative to flow (p=<.0001). Under sustained low flow in dogs, there was significant rest redistribution of 99mTc-sestamibi (P<0.0001) and 201Tl (P=0.005) between early and late imaging relative to flow.
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