Key result
Inoculation of "Runde" virus mixed with hyperimmune mouse serum or unheated guinea pig serum into newborn mice resulted in persistent infection and chronic disease rather than acute fatal CNS disease.
The study suggests an immunological basis for 'Runde' virus persistence and chronic disease in suckling mice when exposed to specific antisera.
Hypothesis-generating for immune-mediated viral persistence in mice; leaves open relevance to human CNS disease.
Antisera from various animal species containing antibodies to "Runde" virus were not able to neutralize virus infection in newborn mice, the outcome of which is an acute, fatal CNS disease. There was, however, one noticeable exception. Mixtures of virus and hyperimmune mouse serum or ascitic fluid inoculated intracerebrally into newborn mice resulted in a persistent infection and a chronic disease which had previously only been recognized in 2 to 3-week-old mice inoculated with "Runde" virus. A serum pool from persistently infected mice had the same effect, though this was less pronounced. The addition of unheated guinea pig serum to the virus-hyperimmune serum mixtures reinforced the tendency to persistence and chronic disease, and unheated guinea pig serum alone modified the infection in the same way. The results suggest an immunological basis for the virus persistence and chronic disease in suckling mice.
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Terje Traavik (1979) studied "Runde" virus infection. Hyperimmune mouse serum, ascitic fluid, and unheated guinea pig serum vs. Antisera from other animal species was evaluated on Development of persistent infection and chronic disease. Inoculation of "Runde" virus mixed with hyperimmune mouse serum or unheated guinea pig serum into newborn mice resulted in persistent infection and chronic disease rather than acute fatal CNS disease.
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