The critical aspartate residue required for eicosanoid sensitivity in Kir3 channels is the same residue required for Na+ regulation of PIP2 gating.
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Identifies shared residue linking eicosanoid sensitivity and Na+-PIP2 gating in Kir3 channels; hypothesis-generating for cardiac K+ modulation.
Rogalski et al. (2001) studied this question.
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