Key result
Secreted phospholipase A2 group V protects against angiotensin II-induced aortic dissection in mice by mobilizing vasoprotective lipids like oleic and linoleic acids.
Why the study?
Aortic dissection is a life-threatening aortopathy whose underlying mechanisms remain incompletely understood, while epidemiological evidence suggests unsaturated fatty acids improve cardiovascular health.
Does dietary supplementation with oleic or linoleic acid prevent aortic dissection in sPLA2-V-deficient mice infused with angiotensin II?
Does dietary supplementation with oleic or linoleic acid prevent aortic dissection in sPLA2-V-deficient mice infused with angiotensin II?
Endothelial sPLA2-V protects against angiotensin II-induced aortic dissection by mobilizing oleic and linoleic acids, suggesting a potential therapeutic target for preventing aortic dissection.
Aortic dissection is a life-threatening aortopathy involving separation of the aortic wall, whose underlying mechanisms are still incompletely understood. Epidemiological evidence suggests that unsaturated fatty acids improve cardiovascular health. Here, using quantitative RT-PCR, histological analyses, magnetic cell sorting and flow cytometry assays, and MS-based lipidomics, we show that the activity of a lipid-metabolizing enzyme, secreted phospholipase A 2 group V (sPLA 2 -V), protects against aortic dissection by endogenously mobilizing vasoprotective lipids. Global and endothelial cell–specific sPLA 2 -V–deficient mice frequently developed aortic dissection shortly after infusion of angiotensin II (AT-II). We observed that in the AT-II–treated aorta, endothelial sPLA 2 -V mobilized oleic and linoleic acids, which attenuated endoplasmic reticulum stress, increased the expression of lysyl oxidase, and thereby stabilized the extracellular matrix in the aorta. Of note, dietary supplementation with oleic or linoleic acid reversed the increased susceptibility of sPLA 2 -V–deficient mice to aortic dissection. These findings reveal an unexplored functional link between sPLA 2 -driven phospholipid metabolism and aortic stability, possibly contributing to the development of improved diagnostic and/or therapeutic strategies for preventing aortic dissection.
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Watanabe et al. (2020) studied Aortic dissection. sPLA2-V deficiency vs. Wild-type was evaluated on Development of aortic dissection after angiotensin II infusion. Secreted phospholipase A2 group V protects against angiotensin II-induced aortic dissection in mice by mobilizing vasoprotective lipids like oleic and linoleic acids.
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