Experimental study demonstrates miR-1 and miR-133a suppress OSMR and FGFR signaling to prevent cardiomyocyte dedifferentiation, indicating microRNAs preserve adult cardiac cell identity.
The muscle-specific miR-1 and miR-133a RNAs lock cardiomyocytes in a differentiated state by suppressing OSMR/FGFR signaling.
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Valussi et al. (2021) studied this question.