Key result
Tinidazole and metronidazole reduced postoperative morbidity compared to placebo, with no advantage of a 7-day metronidazole course over a single preoperative dose of tinidazole.
Why the study?
Does tinidazole or metronidazole prophylaxis reduce post-operative morbidity in women undergoing elective hysterectomy?
RCT
Does tinidazole or metronidazole prophylaxis reduce post-operative morbidity in women undergoing elective hysterectomy?
A single preoperative dose of tinidazole is as effective as a 7-day course of metronidazole in reducing postoperative morbidity after elective hysterectomy.
Answers are grounded in this paper and cite their sources.
Single-dose tinidazole equals 7-day metronidazole in reducing post-hysterectomy morbidity; confirms preoperative antibiotic prophylaxis benefit versus placebo.
Summary: A prospective randomised controlled study has demonstrated that tinidazole and metronidazole are effective in reducing post‐operative morbidity in women undergoing the operation of elective hysterectomy. Postoperative febrile morbidity, pelvic infection and antibiotic usage were reduced in those patients receiving either tinidazole or metronidazole as compared with a placebo group, but no advantage could be demonstrated with metronidazole administration preoperatively and for 7 days postoperatively as opposed to a single preoperative dose of tinidazole.
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Cocks et al. (1981) conducted an RCT in Elective hysterectomy. Tinidazole and Metronidazole vs. Placebo was evaluated on Post-operative morbidity (febrile morbidity, pelvic infection, antibiotic usage). Tinidazole and metronidazole reduced postoperative morbidity compared to placebo, with no advantage of a 7-day metronidazole course over a single preoperative dose of tinidazole.
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