Abstract 4-O-(3,4-Di-O-benzyl-2,6-dicarbobenzoxyamino-2,6-dideoxy-α-d-glucopyranosyl)-N,N′-dicar-bobenzoxy-2-deoxystreptamine has been prepared from neamine and condensed with 3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-d-glucopyranosyl chloride by a modified Koenigs-Knorr reaction to give an α,α-diglycoside. The identity of the product with a substance of the same structure derived from natural kanamycin B was shown. Removal of the masking groups from the product gave the synthetic kanamycin B, which was identical with natural kanamycin B.
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Umezawa et al. (1969) studied this question.
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