Abstract 4-O-(3-O-Benzyl-2-carbobenzoxyamino-4,6-O-isopropylidene-2-deoxy-α-d-glucopyranosyl)-N,N′-dicarbobenzoxy-2-deoxystreptamine has been prepared from paromamine and condensed with 3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-d-glucopyranosyl chloride by a modified Koenigs-Knorr reaction. The identity of the synthetic α,α-diglycoside with a substance of the same structure derived from natural kanamycin C was shown. Removal of the masking groups gave the product identical with natural kanamycin C.
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Umezawa et al. (1969) studied this question.
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