Water soluble tumor-specific transplantation antigens were prepared from 2 different syngeneic methylcholanthrene-induced guinea pig sarcomas. The presence of tumor-specific transplantation antigens in each of these tumors was confirmed by the fact that temporary tumor growth of each tumor in syngeneic hosts induced immunity to itself but not to the other tumor. Soluble extracts of these tumors were prepared by a procedure known to liberate soluble tissue antigens. Guinea pigs immunized with these tumor extracts proved to be significantly more resistant to growth of the immunizing tumor than untreated guinea pigs or guinea pigs immunized with extracts derived from a different tumor. The solubilization of carcinogen-induced tumor-specific transplantation antigens now affords the opportunity for further purification and chemical characterization of these substances.
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Holmes et al. (1970) studied this question.
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