Key result
Sera from adult monkeys and immature monkeys treated with anterior pituitary extract failed to neutralize the poliomyelitis virus, showing no correlation with maturity or physiological variations.
The study demonstrates that neither maturity nor physiological variations such as menstruation induced by anterior pituitary extract correlate with the ability of monkey serum to neutralize the poliomyelitis virus.
Monkey sera lack maturity- or pituitary-linked poliomyelitis neutralization; leaves open other serum immunity factors for investigation.
Twelve specimens of serum from nine adult male monkeys failed to neutralize the virus of poliomyelitis. 2. Ten samples of serum obtained from three adult female monkeys at various phases of the menstrual cycle likewise proved incapable of neutralizing the virus. An eleventh serum, drawn from a fourth female 32 days postpartum, gave irregular results. It neutralized once and failed to do so on second test. This is the only suggestion in our experiments that a physiological factor may play a part in poliomyelitis immunity. 3. Fourteen sera from ten immature monkeys caused to menstruate by treatment with anterior pituitary extract were devoid of virucidal property. This treatment failed also to induce a systemic resistance to intracerebral injections of virus in the nine monkeys of the same group available for test. 4. We were unable to demonstrate in our monkeys a correlation between virucidal capacity of the serum and maturity or physiological variations as exemplified by menstruation.
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Hudson et al. (1934) studied Poliomyelitis immunity (n=23). Anterior pituitary extract and physiological variations (maturity/menstruation) was evaluated on Neutralization of the poliomyelitis virus. Sera from adult monkeys and immature monkeys treated with anterior pituitary extract failed to neutralize the poliomyelitis virus, showing no correlation with maturity or physiological variations.