wenty-nine analogs of 2-deoxystreptamine have been tested to determine whether they are converted to antibiotics in 2-deoxystreptamine-negative mutants of Streptomyces fradiae, S. rimosus forma paromomycinus and S. kanamyceticus. Some analogs substituted at the 2-position of 2-deoxystreptamine undergo bioconversion to active antibiotics.
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Shier et al. (1973) studied this question.
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