Key result
Plant-made vaccines are a promising technology to fight picornaviruses, with several candidates showing preclinical efficacy in inducing humoral and cellular responses.
Why the study?
Picornaviruses cause serious health problems worldwide, making low-cost vaccines a priority to ensure coverage, particularly in developing and low-income countries.
Plant-made vaccines represent a promising, low-cost technology for fighting picornaviruses, particularly in developing countries.
Answers are grounded in this paper and cite their sources.
Promising for low-cost picornavirus vaccines in developing countries; leaves open confirmation of clinical efficacy.
INTRODUCTION: are pathogens that generate serious problems for human and animal health worldwide. Vaccination is an attractive approach to fight against picornaviruses. In this regard, the development of low-cost vaccines is a priority to ensure coverage; especially in developing and low-income countries. In this context, plant-made vaccines are a convenient technology since plant cells are low-cost bioreactors capable of producing complex antigens that preserve their antigenic determinants; moreover, they can serve as biocapsules to achieve oral delivery. AREAS COVERED: In the present review the advances in the development of plant-made vaccines against picornaviruses are summarized and placed in perspective. The main diseases that have been targeted using this approach include Poliovirus, Food and mouth disease virus, Hepatitis A virus, and Enterovirus 71. EXPERT OPINION: Several vaccine candidates against picornavirus have been characterized at the preclinical level; with many of them capable of inducing humoral and cellular responses that led to neutralization of pathogens when evaluated in vitro and test animal challenge assays. Plant-made vaccines are a promise to fight picornaviruses; especially in the developing world where limited resources hamper vaccination coverage. A critical analysis of the road ahead for this technology is provided.
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Bolaños−Martínez et al. (2020) conducted a review in Picornavirus infections. Plant-made vaccines was evaluated. Plant-made vaccines are a promising technology to fight picornaviruses, with several candidates showing preclinical efficacy in inducing humoral and cellular responses.
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