A Critical Analysis of the Use of Salicylazosulfapyridine in Chronic Ulcerative Colitis

Article1 November 1959A CRITICAL ANALYSIS OF THE USE OF SALICYLAZOSULFAPYRIDINE IN CHRONIC ULCERATIVE COLITISCHARLES G. MOERTEL, M.D., J. ARNOLD BARGEN, M.D., F.A.C.P.CHARLES G. MOERTEL, M.D.Search for more papers by this author, J. ARNOLD BARGEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-879 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf the many disease states that the internist or general practitioner may be called upon to treat, few if any have proved to be more frustrating to the physician and more demoralizing to the patient than chronic ulcerative colitis. Evaluation of any form of therapy in this disease is a most complex task, since it occurs in varied clinical forms and in varied degrees of severity. In many cases the natural history is one of exacerbations and remissions. Therefore, any therapeutic agent, if given at an opportune time or for a sufficiently long period, may be coincident with an unrelated...Bibliography1. Svartz N: Ett nytt sulfonamidpreparat, Nord. med. 9: 554, 1941. Google Scholar2. Bargen JA: Evaluation of the newer therapy of ulcerative colitis, South. M. J. 41: 646, 1948. CrossrefMedlineGoogle Scholar3. Helander S: On the concentrations of some sulfanilamide derivatives in different organs and tissue structures, Acta physiol. Suppl. 29: 5, 1945. Google Scholar4. Svartz N: Salazopyrin, a new sulfanilamide preparation, Acta med. Scandinav. 110: 577, 1942. CrossrefGoogle Scholar5. Levy CW: Agranulocytose ved salazopyrinbruk meddelelse om et tilfelle, Tidsskr. f. d. norske laegefor. 69: 255, 1949. Google Scholar6. EvansFord RSWP: Studies of the bone marrow in immunological granulocytopenia: following administration of salicylazosulfapyridine, Arch. Int. Med. 101: 244, 1958. CrossrefGoogle Scholar7. SpriggsSmithGriffithTruelove AIRSHSC: Heinz-body anaemia due to salicylazosulphapyridine, Lancet 1: 1039, 1958. CrossrefMedlineGoogle Scholar8. FierstRobinsonLangsamWernerIngegno SMEAAAP: Corticosteroid therapy in chronic ulcerative colitis, J. A. M. A. 163: 1444, 1957. CrossrefMedlineGoogle Scholar9. Morrison LM: Response of ulcerative colitis to therapy with salicylazosulfapyridine, J. A. M. A. 151: 366, 1953. MedlineGoogle Scholar10. Lagercrantz R: Ulcerative colitis in children, Acta paediat. Suppl. 75: 89, 1949. CrossrefGoogle Scholar11. Svartz N: The treatment of ulcerative colitis, Gastroenterologia 86: 683, 1956. CrossrefMedlineGoogle Scholar12. Kirsner JB: Personal communication to the authors. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication May 12, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 20, 1959.From the Section of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.Requests for reprints should be addressed to the Section of Publications, Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: Treatment outcomes of 847 patients in clinical practiceA new paradigm in ulcerative colitis: Regulatory T cells are key factor which induces/exacerbates UC through an immune imbalanceMulticenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitisMultivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label StudyMesalamine delivery systems: do they really make much difference?Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitisSulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerance and side-effects5-Aminosalicylates in inflammatory bowel: disease: Choosing choosing the right doseFIFTY LANDMARK DISCOVERIES IN GASTROENTEROLOGY DURING THE PAST 50 YEARSCONVENTIONAL DRUG THERAPY IN INFLAMMATORY BOWEL DISEASELeukocytapheresis therapy, performed with leukocyte removal filter, for inflammatory bowel diseaseIntermittent therapy with high-dose 5-aminosalicylic acid enemas maintains remission in ulcerative proctitis and proctosigmoiditis5-ASA Preparations in the Treatment of Inflammatory Bowel DiseaseSulfasalazine Therapy in Inflammatory Bowel Disease5-Aminosalicylic acid enemas: Effective agent in maintaining remission in left-sided ulcerative colitisPharmacotherapy of inflammatory bowel diseaseDrug Therapy of Inflammatory Bowel DiseaseRole of the Intestinal Microflora in Ulcerative ColitisOptimum dose of sulphasalazine for maintenance treatment in ulcerative colitis.Comparative evaluation of the action of salazopyridazine and sulfasalazine in the treatment of nonspecific ulcerative colitisSalicylazosulfapyridine in inflammatory bowel diseaseFrontiers in inflammatory bowel diseaseAdverse Reactions during Salicylazosulfapyridine Therapy and the Relation with Drug Metabolism and Acetylator PhenotypeThe metabolism of salicylazosulphapyridine in ulcerative colitis: II The relationship between metabolites and the progress of the disease studied in outpatientsSalicylazosulfapyridine in Clinical PracticeAcetylator phenotype and adverse effects of sulphasalazine in healthy subjectsPancreatitis as an Adverse Reaction to SalicylazosulfapyridineThe medical treatment of ulcerative colitis.Studies of Intestinal MicrofloraThe Management of Ulcerative ColitisChronic ulcerative colitis of childhoodTreatment of Ulcerative ColitisControlled trial of sulphasalazine in the treatment of ulcerative colitisManagement of ulcerative colitis in childrenReferencesNonspecific Ulcerative ColitisSULPHASALAZINE AND SALICYLAZOSULPHADIMIDINE IN ULCERATIVE COLITISUlcerative ColitisThe SulfonamidesAn Assessment of Prednisone, Salazopyrin, and Topical Hydrocortisone Hemisuccinate Used as Out-patient Treatment for Ulcerative ColitisA Comparative Trial of Salazopyrin Prednisone and Hydrocortisone Retention Enemata in the Out-Patient Treatment of Left-Sided Colitis. Preliminary Report 1 November 1959Volume 51, Issue 5Page: 879-889KeywordsAdrenocorticotropic hormoneColitisGraduate medical educationUlcerative colitis Issue Published: 1 November 1959 PDF downloadLoading ...