Key result
Diazepam significantly potentiated the inhibitory action of adenosine on isolated rat vas deferens and guinea-pig left atria, likely due to inhibition of adenosine uptake.
Diazepam potentiates the inhibitory effects of adenosine in isolated cardiac and smooth muscle, likely through inhibition of adenosine uptake.
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Alerts clinicians to possible adenosine potentiation by diazepam in cardiac tissue; leaves open human relevance and interaction risks pending in vivo data.
Clanachan et al. (1980) studied this question. Diazepam vs. Adenosine alone was evaluated on Inhibitory action of adenosine on tissue responses. Diazepam significantly potentiated the inhibitory action of adenosine on isolated rat vas deferens and guinea-pig left atria, likely due to inhibition of adenosine uptake.
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