Key result
Epicardial fatty tissue thickness was significantly higher in patients with lichen planus compared to healthy controls (0.67 mm vs 0.57 mm) and was identified as an independent predictor of the disease.
Why the study?
Lichen planus is a chronic inflammatory disease, and epicardial fatty tissue secretes pro-inflammatory and pro-atherogenic cytokines; this study investigated the predictive value of epicardial fatty tissue thickness evaluated alongside fibrinogen to albumin ratio and other inflammation markers.
Do epicardial fatty tissue thickness and inflammatory markers (FAR, NLR, PLR) predict the presence of lichen planus?
Case-Control (n=110)
Single-blind (echocardiographer blinded to clinical data)
No
Do epicardial fatty tissue thickness and inflammatory markers (FAR, NLR, PLR) predict the presence of lichen planus?
Absolute Event Rate: 0.67% vs 0.57%
p-value: p=0.007
Epicardial fatty tissue thickness and inflammatory markers (FAR, NLR) are independently associated with lichen planus, suggesting a potential link between this chronic inflammatory skin disease and cardiovascular risk markers.
May link lichen planus to cardiovascular risk markers; hypothesis-generating and requires prospective validation.
OBJECTIVE: Lichen planus (LP) is one of the chronic inflammatory diseases. Epicardial fatty tissue (EFT) is the adipose tissue in which pro-inflammatory and pro-atherogenic hormones and cytokines are secreted. We planned to investigate the predictive value of EFT in LP patients by evaluating together with Fibrinogen to albumin ratio (FAR) other inflammation markers. MATERIALS AND METHODS: A total of 53 consecutive LP patients and 57 healthy controls were enrolled in this single-center, prospective, case-control study. Demographic data were recorded; blood tests were obtained from both groups. Then, EFT thickness was measured by echocardiography. RESULTS: Fibrinogen, FAR, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, and EFT thickness were higher in LP patients (p < 0.05, for all). EFT was positively correlated with FAR (r = 0.306, p = 0.001), NLR (r = 0.240, p = 0.011), and PLR (r = 0.297, p = 0.002). ROC analysis indicated that FAR could predict LP with a sensitivity of 83 % and a specificity of 44 %; NLR could predict LP with a sensitivity of 80 % and a specificity of 46 %; EFT could predict LP with a sensitivity of 79 % and a specificity of 54 %. In the binary logistic regression analysis NLR, FAR, and EFT were found to be independent predictors of LP. CONCLUSION: We found a relationship between LP and FAR together with other inflammation parameters NLR, and PLR. We demonstrated for the first time that FAR, NLR and EFT were independent predictors of LP. Also, there was a significant relationship between these parameters and EFT (Tab. 4, Fig. 1, Ref. 30). Text in PDF www.elis.sk Keywords: lichen planus, epicardial fatty tissue, fibrinogen, albumin, neutrophil, lymphocyte.
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Tosun et al. (2023) conducted a case-control in Lichen planus (n=110). Lichen planus vs. Healthy controls was evaluated on Mean epicardial fatty tissue (EFT) thickness in mm (p=0.007). Epicardial fatty tissue thickness was significantly higher in patients with lichen planus compared to healthy controls (0.67 mm vs 0.57 mm) and was identified as an independent predictor of the disease.
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