Key result
Rats with pilocarpine-induced epilepsy submitted to an AMI model presented significant electrical conductivity alterations, including increased QRS and reduced QT intervals compared to controls (P<0.01).
Why the study?
Does a pilocarpine-induced epilepsy model alter electrocardiographic parameters during cardiac ischemia and reperfusion in rats?
RCT (n=26)
Randomly divided
Does a pilocarpine-induced epilepsy model alter electrocardiographic parameters during cardiac ischemia and reperfusion in rats?
In a rat model, pilocarpine-induced epilepsy significantly alters cardiac electrical conductivity and electrocardiographic intervals during acute myocardial ischemia and reperfusion.
ECG alterations in epileptic rats during ischemia warrant no clinical change; leaves open translational relevance to human arrhythmia risk.
The present study evaluated electrocardiographic alterations in rats with epilepsy submitted to an acute myocardial infarction (AMI) model induced by cardiac ischemia and reperfusion. Rats were randomly divided into two groups: control (n=12) and epilepsy (n=14). It was found that rats with epilepsy presented a significant reduction in atrioventricular block incidence following the ischemia and reperfusion procedure. In addition, significant alterations were observed in electrocardiogram intervals during the stabilization, ischemia, and reperfusion periods of rats with epilepsy compared to control rats. It was noted that rats with epilepsy presented a significant increase in the QRS interval during the stabilization period in relation to control rats (P<0.01). During the ischemia period, there was an increase in the QRS interval (P<0.05) and a reduction in the P wave and QT intervals (P<0.05 for both) in rats with epilepsy compared to control rats. During the reperfusion period, a significant reduction in the QT interval (P<0.01) was verified in the epilepsy group in relation to the control group. Our results indicate that rats submitted to an epilepsy model induced by pilocarpine presented electrical conductivity alterations of cardiac tissue, mainly during an AMI episode.
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Tavares et al. (2015) conducted an RCT in Epilepsy and acute myocardial infarction (n=26). Epilepsy model induced by pilocarpine vs. Control group was evaluated on Electrocardiographic alterations (QRS, P wave, QT intervals) and atrioventricular block incidence (p=<0.01). Rats with pilocarpine-induced epilepsy submitted to an AMI model presented significant electrical conductivity alterations, including increased QRS and reduced QT intervals compared to controls (P<0.01).
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