Key result
Subacute myocarditis was diagnosed in 10 of 40 athletes with echocardiographic signs of pathological left ventricular remodeling, characterized by elevated immunobiochemical markers and antibody titers.
Observational (n=163)
Immunobiochemical markers and antimyocardial antibody titers can help identify subacute myocarditis in young athletes presenting with echocardiographic signs of left ventricular remodeling and infectious risk factors.
May support targeted marker testing in athletes with LV remodeling; leaves open need for prospective validation before practice change.
Aim. Development of informative differential diagnostic criteria of inflammatory myocardial involvement in young athletes. Methods. A total of 163 athletes (swimmers, football players and sailing athletes) aged 9 to 24 years (mean age 14.74±0,23 years, SD=3.03) were examined. Complete clinical and functional examination was performed. Remodeling of the left ventricle was studied in accordance with R. Devereux (1992) and B. Maron (2005) echocardiographic criteria. Myocardial morphometry results were compared with immunobiochemical markers of myocardial damage and titer of antimyocardial antibodies to the endothelium, cardiac conduction system, cardiomyocytes, and smooth muscle. Results. In 10 out of 40 athletes with echocardiographic signs of pathological remodeling of the left ventricle, the indicators of myocardial damage used as immunobiochemical screening tests, were increased, high titers of antimyocardial antibodies (more than 1:160), arrhythmias, sever conduction disorders, and high concentrations of infectious risk factors were revealed, allowing to diagnose subacute myocarditis. Conclusion. Subacute myocarditis should be excluded in athletes with echocardiographic signs of left ventricular myocardial remodeling and a high concentration of «infectious» risk factors based on immunobiochemical markers of myocardial damage and antimyocardial antibodies titer.
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Degtyareva et al. (2015) conducted an observational in Myocarditis (n=163). Pathological left ventricular remodeling vs. Normal left ventricular geometry was evaluated on Diagnosis of subacute myocarditis. Subacute myocarditis was diagnosed in 10 of 40 athletes with echocardiographic signs of pathological left ventricular remodeling, characterized by elevated immunobiochemical markers and antibody titers.
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