Key result
CaV3.2 channels play a prominent role in several pathologies, including neuropathic pain, epilepsy, and cardiac rhythm dysregulation, making them a promising target for future pharmacotherapies.
This review highlights the physiological roles and regulatory mechanisms of CaV3.2 calcium channels, emphasizing their potential as therapeutic targets for various neurological and cardiovascular diseases.
Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.
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Ľubica Lacinová (2017) conducted a review in Neuropathic pain, epilepsy, cardiac rhythm dysregulation, autism spectrum disorders, amyotrophic lateral sclerosis. CaV3.2 channels play a prominent role in several pathologies, including neuropathic pain, epilepsy, and cardiac rhythm dysregulation, making them a promising target for future pharmacotherapies.
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