Cyclic strain induces biphasic elevations in cytosolic Ca2+ in endothelial cells through mobilization of intracellular and extracellular pools, while IP3 generation remains independent of plasma membrane Ca2+ entry.
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These endothelial cell responses leave open the in vivo role of strain-induced Ca2+ signaling; hypothesis-generating for vascular mechanobiology.
Rosales et al. (1997) studied this question.
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