Artificial Kidney in the Treatment of Uremia Associated With Acute Glomerulonephritis (With a Note on Regional Heparinization)

Article1 September 1959ARTIFICIAL KIDNEY IN THE TREATMENT OF UREMIA ASSOCIATED WITH ACUTE GLOMERULONEPHRITIS (WITH A NOTE ON REGIONAL HEPARINIZATION)ANDREW ANDERSON, M.D., WILLEM J. KOLFF, M.D., F.A.C.P.ANDREW ANDERSON, M.D.Search for more papers by this author, WILLEM J. KOLFF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-476 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere has been some reluctance in using the artificial kidney to treat uremia associated with acute glomerulonephritis because it was feared that dialysis might cause or aggravate hypertension and convulsions, and that heparinization might cause cerebral hemorrhage.We hope to show that the artificial kidney deserves a place in the medical management of patients with uremia resulting from acute glomerulonephritis.In 1947 one of us1reported the first five cases of acute glomerulonephritis treated with the artificial kidney. All five were in desperate condition and, of the three who recovered, one had hypertension and one had pulmonary edema at the...Bibliography1. Kolff WJ: New ways of treating uraemia: the artificial kidney, peritoneal lavage, intestinal lavage, 1947, J. & A. Churchill, Ltd., London. Google Scholar2. AlwallErlansonNymanTornberg NPMA: On the artificial kidney. XXX. Casuistics of further 26 severe cases of glomerularnephritis treated conservatively and, on vital indication, by dialysis (26 cases) and ultrafiltration (2 cases), Acta med. Scandinav. 152: 417, 1955. CrossrefMedlineGoogle Scholar3. CarterAoyamaMercerKolff FHSRDWJ: Hemodialysis in children; report of five cases, J. Pediat. 51: 125, 1957. CrossrefMedlineGoogle Scholar4. PalmerHenryEden RAEJ: Management of acute renal failure, Canad. M. A. J. 77: 11, 1957. MedlineGoogle Scholar5. HamburgerRichet JA: Enseignements tirés de la pratique du rein artificiel pour l'interprétation de désordres électrolytiques de l'urémie aiguë, Rev. fr. clin. biol. 1: 39, 1956. MedlineGoogle Scholar6. Burke EC: Management of complications of acute nephritis in childhood, Proc. Staff Meet., Mayo Clin. 33: 23, 1958. MedlineGoogle Scholar7. LukemeyerSoper GTHA: Artificial kidney, J. Indiana M. A. 49: 647, 1956. Google Scholar8. KolffWatschinger WJB: Further development of coil kidney; disposable artificial kidney, J. Lab. and Clin. Med. 47: 969, 1956. MedlineGoogle Scholar9. GordonRichardsPerkins LAVHA: Studies in regional heparinization. I. Use of simultaneous neutralization with protamine; preliminary studies, New England J. Med. 255: 1025, 1956. CrossrefMedlineGoogle Scholar10. NakamotoHolmes SJH: Experiences in regional heparinization, presented at the American Society for Artificial Internal Organs, Philadelphia, April 13, 1958. Google Scholar11. RigdonWilson RHH: Capillary permeability and inflammation in rabbits given heparin, Arch. Surg. 43: 64, 1941. CrossrefGoogle Scholar12. Cohen SM: Massive cerebral hemorrhage following heparin therapy in subacute bacterial endocarditis. Report of 2 cases with review of literature, J. Mt. Sinai Hosp. 16: 214, 1949. MedlineGoogle Scholar13. Case Records of the Massachusetts General Hospital; Case 36341, New England J. Med. 243: 308, 1950. MedlineGoogle Scholar14. : Acute glomerulonephritis with right intracerebral hemorrhage, Arizona Med. 10: 184, 1953. MedlineGoogle Scholar15. PedigoNolan GWDE: Subarachnoid hemorrhage complicating hemorrhagic nephritis, Ohio M. J. 43: 743, 1947. MedlineGoogle Scholar16. Case Records of the Massachusetts General Hospital; Case 14341; Coma—cause?, New England J. Med. 199: 736, 1928. CrossrefGoogle Scholar17. DewarWalmsley HAR: Relapsing fever with nephritis and subarachnoid haemorrhage, Lancet 2: 630, 1945. CrossrefMedlineGoogle Scholar18. BywatersJoekes EGAM: Artificial kidney: its clinical application in treatment of traumatic anuria, Proc. Roy. Soc. Med. 41: 420, 1948. CrossrefMedlineGoogle Scholar19. FishmanKroopLeiterHyman APIGHEA: Experiences with the Kolff artificial kidney, Am. J. Med. 7: 15, 1949. CrossrefMedlineGoogle Scholar20. HollanderSterlingDoane GJAJC: New type of artificial kidney. II. Treatment of acute and chronic uremia, J. Urol. 69: 753, 1953. CrossrefMedlineGoogle Scholar21. Shaw CC: Kolff-Merrill artificial kidney; clinical application in acute renal insufficiency, California Med. 82: 293, 1955. MedlineGoogle Scholar22. KeitzerFordMiller WAMLEW: Clinical experience with Skeggs-Leonards artificial kidney, J. Urol. 72: 629, 1954. CrossrefMedlineGoogle Scholar23. MaherBroadbent FTJC: Extracorporeal hemodialysis in management of acute renal failure, J. A. M. A. 166: 608, 1958. CrossrefMedlineGoogle Scholar24. AlwallNorviitSteins NLAM: On artificial kidney; clinical experiences of dialytic treatment of uremia, Acta. med. Scandinav. 132: 587, 1949. CrossrefGoogle Scholar25. AlwallLunderquistTornberg NAA: On artificial kidney; casuistics of 14 cases of acute tubular nephritis (lower nephron nephrosis, etc.) with anuria or severe oliguria of 4-28 days duration, treated conservatively and, on vital indication, with dialysis, Acta med. Scandinav. 147: 19, 1953. CrossrefMedlineGoogle Scholar26. Alwall N: Erfahrungen mit der künstlichen Niere, Arch. f. klin. Chir. 287: 579, 1957. Google Scholar27. OberReidRomneyMerrill WEDESLJP: Renal lesions and acute renal failure in pregnancy, Am. J. Med. 21: 781, 1956. CrossrefMedlineGoogle Scholar28. Merrill JP: Use of artificial kidney in treatment of uremia, Bull. New York Acad. Med. 28: 523, 1952. MedlineGoogle Scholar29. Merrill JP: Medical progress; artificial kidney, New England J. Med. 246: 17, 1952. CrossrefMedlineGoogle Scholar30. OrbisonChristianPeters JLCLE: Studies on experimental hypertension and cardiovascular disease; method for rapid production of malignant hypertension in bilaterally nephrectomized dogs, Arch. Path. 54: 185, 1952. Google Scholar31. KolffPageCorcoran WJIHAC: Pathogenesis of renoprival cardiovascular disease in dogs, Am. J. Physiol. 178: 237, 1954. CrossrefMedlineGoogle Scholar32. Fishberg AM: Hypertension and nephritis, 1949, Bailliere, Tindal and Cox, London. Google Scholar33. AoyamaKolff SWJ: Treatment of renal failure with disposable artificial kidney: results in 52 patients, Am. J. Med. 23: 565, 1957. CrossrefMedlineGoogle Scholar34. PalmerHenry RAEW: Clinical course of acute renal failure: observations on 54 cases, Canad. M. A. J. 77: 1078, 1957. MedlineGoogle Scholar35. Kolff WJ: Artificial kidney—past, present and future, Circulation 15: 285, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 11, 1958.From the Department of Artificial Organs, Division of Research, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute, Cleveland, Ohio.†This work was supported by a grant from the Life Insurance Medical Research Foundation.‡Formerly Fellow in the Department of Artificial Organs. Present address: Royal Victoria Hospital, Montreal, Canada.§Baxter Laboratories, Morton Grove, Illinois.Requests for reprints should be addressed to Willem J. Kolff, M.D., Head, Department of Artificial Organs, Cleveland Clinic, 2020 East Ninety-third Street, Cleveland 6, Ohio. 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HALLAcute Renal Failure—1960EXPANDING THE INDICATIONS FOR TREATMENT WITH THE ARTIFICIAL KIDNEY 1 September 1959Volume 51, Issue 3Page: 476-487KeywordsEdemaGlomerulonephritisHemorrhageHypertensionKidneysMedical dialysisPeritonitisPulmonary hypertensionUltrafiltrationUrea Issue Published: 1 September 1959 PDF downloadLoading ...