Erythrophilic γ-globulin that binds to the autologous cell membrane influences the shape of the erythrocyte in vitro. In its absence, the cell is rounded and crenated with spikelike projections arising sharply from the membrane. The addition of erythrophilic γ-globulin immediately restores the original biconcave disc structure. Isolated Fab and F(ab)2 fragments, like the parent molecule, bind in low ionic strength isotonic media and dissociate at high ionic strength. A modified method that is regularly reproducible was devised for better separation of Fab and Fc fragments of the γ-globulin molecule.
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Lahiri et al. (1970) studied this question.
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