The syntheses of two metabolites of flufenamic acid, 5-hydroxy-N-(ααα-trifluoro-m-tolyl)anthranilic acid and N-(4-hydroxy-ααα-trifluoro-m-tolyl)anthranilic acid, are described. Syntheses of a number of other N-aryl-anthranilic acids, mono-, di-, tri-, and tetra-substituted in the aryl ring lacking a carboxy-group, and with substituents in both aryl rings, are reported.
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Bowman et al. (1973) studied this question.