A new ring-forming reaction has been developed in which nitriles act as 1,1-dianion synthons with biselectrophiles. The cyclizations are highly diastereoselective and are capable of forming two adjacent quaternary centers with complete selectivity (see scheme; LiDBB=lithium di-tert-butylbiphenylide).
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Rychnovsky et al. (2003) studied this question.
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