Key result
First-trimester maternal serum biomarker concentrations (beta-HCG, PAPP-A, s-FLT-1, PlGF) had no significant effect on the pulsatility index of the ductus venosus and uterine arteries.
Why the study?
The study aimed to evaluate the effect of first-trimester s-FLT-1 and PlGF concentrations on the pulsatility index of the ductus venosus and right and left uterine arteries.
Do maternal serum biomarkers (b-HCG, PAPP-A, s-FLT-1, PlGF) correlate with the pulsatility index of the ductus venosus and uterine arteries in first-trimester pregnant women?
Observational (n=108)
Do maternal serum biomarkers (b-HCG, PAPP-A, s-FLT-1, PlGF) correlate with the pulsatility index of the ductus venosus and uterine arteries in first-trimester pregnant women?
First-trimester maternal serum biomarkers (b-HCG, PAPP-A, s-FLT-1, PlGF) do not significantly correlate with uterine artery or ductus venosus pulsatility indices, though PAPP-A and PlGF are associated with risks of fetal growth restriction and preeclampsia.
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Does not alter first-trimester screening; leaves open independent predictive roles of biomarkers versus Doppler for preeclampsia and FGR.
Background: In this study, we aimed to evaluate the effect of s-FLT-1 and PlGF concentrations in women in the first trimester of pregnancy on the pulsatility index of the ductus venosus and the right and left uterine arteries. Methods: A total of 108 pregnant women in their first trimester were included in the study, with 87 assigned to the experimental group and 21 to the control group. Ultrasound examination were performed to measure the uterine artery pulsatility index, resistance index, ductus venosus pulsatility index, and blood sampling levels of biomarkers such as b-HCG; PAPP-A; s-FLT-1 and PlGF. Results: There was a significant negative relationship between PAPP-A concentration and the risk of fetal growth restriction, and a significant negative relationship between PlGF concentration and the risk of preeclampsia and fetal growth restriction in women in their first trimester of pregnancy. There was also a significant positive relationship between sFLT-1/PLGF ratio and the risk of developing preeclampsia. No significant relationships were found between the concentrations of biomarkers beta-HCG, PAPP-A, sFLT-1, PlGF, and any of the parameters PIUARt, PIUALt, Mean uterine arteries, and DVPI. Summary: In conclusion, this study did not find conclusive evidence to support the hypothesis that beta-HCG, PAPP-A, s-FLT-1, and PlGF concentrations in women in the first trimester of pregnancy have a significant effect on the Pulsatility Index of the ductus venosus and the Right and left Uterine Arteries. Further research is needed to investigate these potential associations.
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Karpów-Greiner et al. (2023) conducted an observational in Pregnancy (n=108). Maternal serum biomarkers (beta-HCG, PAPP-A, s-FLT-1, PlGF) vs. Control group was evaluated on Pulsatility index of the ductus venosus and the right and left uterine arteries. First-trimester maternal serum biomarker concentrations (beta-HCG, PAPP-A, s-FLT-1, PlGF) had no significant effect on the pulsatility index of the ductus venosus and uterine arteries.
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