An in vitro assay is described which simultaneously tests for the superoxide dismutase-like activity of low-molecular-weight copper chelates and their stability in the presence of excess EDTA. The EDTA is introduced to simulate the competitive endogenous ligands a copper-chelating drug will encounter in plasma and other body fluids. Under the conditions of the assay, antirheumatic drugs of the D-penicillamine type are clearly distinguished both from nonsteroidal anti-inflammatories and from some drugs which chelate copper but lack antirheumatic activity.
No takes yet. Share an insight, caveat, or question.
Roberts et al. (1985) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: