Key result
Pre-conception cardiovascular risk factor burden was not a statistically significant predictor of adverse pregnancy outcomes in pregnant women with cardiovascular disease (p=0.139).
Why the study?
The study investigated associations between pre-conception cardiovascular risk factor burden and adverse pregnancy outcomes in women with cardiovascular disease.
Cohort (n=63)
No
p-value: p=0.139
In pregnant women with cardiovascular disease, pre-conception cardiovascular risk factor burden was not significantly associated with overall adverse pregnancy outcomes, though higher risk factor burden was seen in those with pre-term birth.
Pre-conception risk factor burden should not guide pregnancy risk stratification in CVD; leaves open association with pre-term birth for prospective study.
We investigated associations between pre-conception cardiovascular risk factor burden and adverse pregnancy outcomes (APOs) in women with cardiovascular disease (CVD). We created a patient registry from our cardio-obstetrics program. APOs were defined as intrauterine growth restriction (IUGR), hypertensive disorder of pregnancy (HDP), and pre-term birth. Analysis included 63 women. 42 (66.7 %) experienced no APOs, while 21 (33.3 %) did; 18 (28.6 %), 3 (4.8 %), and 12 (19.0 %) developed an HDP, IUGR, or delivered pre-term, respectively. Pre-conception risk burden was not a significant predictor of APO development ( p = 0.139). However, patients with pre-term delivery had a significantly higher number of risk factors ( p < 0.001), as did patients with chronic hypertension with superimposed HDP ( p < 0.001). Women delivering pre-term have higher risk factor burdens. Since pre-term birth is associated with future CVD in women independent of cause, optimization of preconception cardiovascular health could help mitigate these risks in an already vulnerable population.
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Nemov et al. (2025) conducted a cohort in Cardiovascular disease in pregnancy (n=63). Pre-conception cardiovascular risk factor burden vs. Lower or no cardiovascular risk factor burden was evaluated on Development of an adverse pregnancy outcome (fetal growth restriction, pre-term birth, or hypertensive disorder of pregnancy) (p=0.139). Pre-conception cardiovascular risk factor burden was not a statistically significant predictor of adverse pregnancy outcomes in pregnant women with cardiovascular disease (p=0.139).
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