Prognosis in the Neurologic Manifestations of Pernicious Anemia

Four types of disturbed neurologic function occur in pernicious anemia: (1) cerebral, (2) olfactory, (3) peripheral nerve and posterior columns of the spinal cord, and (4) lateral columns of the spinal cord. The neurologic prognosis depends upon the specific type of disability present, its severity, duration, and the adequacy of treatment. With intensive use of highly potent liver extracts intramuscularly the prognosis is far better than generally recognized. Serious neurologic residuals can be avoided if the diagnosis is made reasonably early.