Key result
In a computational model, cardiac output in single ventricle circulation was highly dependent on TCPC resistance (sensitivity=-0.88 l/min/WU) compared to biventricular circulation (-0.064 l/min/WU).
Why the study?
Does TCPC resistance impact resting and exercise hemodynamics in a single ventricle circulation model?
Population
Lumped parameter model of single ventricle circulation, using parameters derived from catheterization data…
Comparison
Simulation of varying total cavopulmonary… vs Biventricular circulation model
Design
Preclinical
Authors
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TCPC resistance may constrain single ventricle hemodynamics; leaves open therapeutic targeting pending human validation.
Does TCPC resistance impact resting and exercise hemodynamics in a single ventricle circulation model?
Effect estimate: sensitivity=-0.88 l.min(-1).WU(-1)
TCPC resistance significantly impacts resting hemodynamics and exercise capacity in patients with single ventricle physiology, primarily due to increased afterload and decreased preload.
Sundareswaran et al. (2008) studied Single ventricle circulation with total cavopulmonary connection (n=40). Total cavopulmonary connection (TCPC) resistance vs. Biventricular circulation was evaluated on Cardiac output dependence on TCPC resistance (sensitivity=-0.88 l.min(-1).WU(-1)). In a computational model, cardiac output in single ventricle circulation was highly dependent on TCPC resistance (sensitivity=-0.88 l/min/WU) compared to biventricular circulation (-0.064 l/min/WU).
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