Key result
Anisodamine and anisodine possess alpha 1-adrenoceptor blocking properties in rat tissues, with anisodamine showing greater potency than anisodine.
Anisodamine possesses alpha 1-adrenoceptor blocking properties which may contribute to its salutary effects on the microcirculation in acute circulatory shock.
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Alpha1 blockade may mediate anisodamine microcirculatory effects in shock; leaves open translation from rat data to clinical use.
Varma et al. (1986) studied this question. Anisodamine and anisodine vs. Classical muscarinic receptor and adrenoceptor blocking agents was evaluated on Alpha 1-adrenoceptor blocking properties. Anisodamine and anisodine possess alpha 1-adrenoceptor blocking properties in rat tissues, with anisodamine showing greater potency than anisodine.
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