Key result
In healthy elderly volunteers, acute hyperhomocysteinaemia induced by methionine loading resulted in no overall significant change in peripheral arterial pulse wave velocity compared with placebo.
Why the study?
Does an acute increase in plasma homocysteine produced by methionine loading increase pulse wave velocity in healthy elderly volunteers?
RCT (n=20)
Double-blind
Randomized
Does an acute increase in plasma homocysteine produced by methionine loading increase pulse wave velocity in healthy elderly volunteers?
In healthy elderly volunteers, acute hyperhomocysteinaemia induced by methionine loading did not significantly reduce peripheral arterial distensibility but did acutely worsen lipid profiles and increase systolic blood pressure.
Acute hyperhomocysteinaemia does not alter pulse wave velocity; challenges presumed direct effect on arterial stiffness in the elderly.
OBJECTIVE: To test the hypothesis that an acute increase in plasma homocysteine produced by methionine is associated with an acute increase in pulse wave velocity. DESIGN: A double blind, cross over, placebo controlled design was used and pulse wave velocity, plasma homocysteine, total cholesterol: high density lipoprotein ratio, plasma triglyceride, oxidised low density lipoprotein cholesterol concentrations, apolipoproteins A1 and B, and C reactive protein were measured between 12.5 and 20 hours after methionine loading or placebo. RESULTS: Between 12.5 and 20 hours after exposure to a methionine loading test, arterial pulse wave velocity showed no significant difference compared with placebo. At 12 hours after exposure to the methionine loading test, in the presence of a controlled diet, triglyceride concentration significantly increased by 32.6% (p<0.02), cholesterol: high density lipoprotein ratio increased significantly by 22.5% (p<0.05) compared with placebo. Simultaneously, systolic blood pressure increased significantly by 4.9% (p<0.02). CONCLUSION: In elderly volunteers, acute hyperhomocysteinaemia induced by methionine loading resulted in no overall significant delayed reduction in peripheral arterial distensibility. A significant deterioration in the lipid profile and increased blood pressure was seen during acute hyperhomocysteinaemia.
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Hart et al. (2006) conducted an RCT in Healthy elderly volunteers (n=20). Methionine loading vs. Placebo was evaluated on Pulse wave velocity (PWV) between 12.5 and 20 hours. In healthy elderly volunteers, acute hyperhomocysteinaemia induced by methionine loading resulted in no overall significant change in peripheral arterial pulse wave velocity compared with placebo.
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