Key result
Patients with Buerger's disease had significantly higher levels of prothrombotic factors, including annexin V (P<0.0003) and factor VII (P<0.0001), compared to healthy controls.
Why the study?
Are plasma prothrombotic factors elevated in patients with Buerger's disease compared to healthy controls?
Case-Control (n=37)
Are plasma prothrombotic factors elevated in patients with Buerger's disease compared to healthy controls?
Patients with Buerger's disease exhibit elevated prothrombotic and fibrinolytic factors, suggesting a role for hemostatic risk factors and hyperhomocysteinemia in its pathogenesis.
Elevated prothrombotic factors may contribute to Buerger's pathogenesis; hypothesis-generating and should not change practice without prospective validation.
The pathogenesis of Buerger' disease (thrombangiitis obliterans; TAO) remains unknown, although a strong association with tobacco use has been established. Blood coagulation and fibrinolytic factors as well as selected clinical chemistry parameters have been evaluated in 37 patients with Buerger's disease. Median levels of prothrombotic factors were higher in patients with TAO than in healthy control: annexin V (P < 0.0003), factor VII (P < 0.0001), factor VIII (P < 0.0000001), factor XI (P < 0.000003), homocysteine (P < 0.014) and fibrinogen (P = 0.00007). Patients with Buerger's disease also showed higher median plasma levels of urokinase type plasminogen activator (uPA) (P < 0.000004), its receptor (uPAR) (P < 0.0008) and uPA complex with plasminogen activator inhibitor 1 (uPA-PAI-1) P < 0.000006). In contrast, plasma concentrations of apolipoprotein A and folic acid were lower in patients with TAO than in control (P < 0.004 and P < 0.0006; respectively). Higher plasminogen (P < 0.05) and cholesterol (P < 0.003), as well as lower folic acid (P < .0.05) levels were noted in the smokers group than in nonsmoking patients. We found higher plasminogen (P < 0.05), factor VII (P < 0.05), total lipids (P < 0.003), cholesterol (P < 0.05) and triglycerides (P < 0.002) levels in patients requiring surgical treatment for limb-threatening ischaemia than the patients treated only conservatively. These findings suggest an important role of haemostatic risk factors in the pathogenesis of Buerger's disease, with special regard to hyperhomocysteinemia that might be aggravated by low serum folic acid level. In patients with aggressive clinical course, disturbances in serum lipids were more pronounced. Further studies are warranted to establish whether diet supplementation of folic acid as well as normalization of lipids balance might influence the clinical course of TAO.
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Hus et al. (2013) conducted a case-control in Buerger's disease (n=37). Buerger's disease vs. Healthy controls was evaluated on Plasma levels of prothrombotic factors. Patients with Buerger's disease had significantly higher levels of prothrombotic factors, including annexin V (P<0.0003) and factor VII (P<0.0001), compared to healthy controls.
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