Key result
Cyclophosphamide administration in young rats induced wide cell-free areas in developing molars that later turned into mineralized osteodentin.
Why the study?
Does cyclophosphamide alter dental development in young rat molars?
Population
36 young Sprague-Dawley rats (18 experimental, 18 control) at 10 and 13 days of age
Comparison
Cyclophosphamide 30 mg/kg body weight dissolved… vs 1 ml 0.9% NaCl administered at 10 and 13 days of…
Design
Preclinical
Follow-up
2 days after the last injection and later
Authors
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May warrant dental monitoring in pediatric cyclophosphamide recipients; leaves open human translation from this rat model.
Does cyclophosphamide alter dental development in young rat molars?
Cyclophosphamide administration in young rats disrupts molar development, leading to abnormal mineralization.
Näsman et al. (1996) studied Dental development (n=36). Cyclophosphamide vs. 0.9% NaCl was evaluated on Changes in developing pulp and roots of molars. Cyclophosphamide administration in young rats induced wide cell-free areas in developing molars that later turned into mineralized osteodentin.
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