L‐Isoleucine and the isomorphic amino acids L‐leucine and L‐valine serve as a model system in the examination of the effects of impurities on the purity and morphology of crystals recovered from batch crystallizations. Factors are determined that influence crystal purity and, concomitantly, crystal size and shape. Characteristics of the L‐isoleucine crystal are determined by X‐ray analysis and compare favorably with the literature. These and literature characteristics of L‐leucine and L‐valine are used in simulations to evaluate possible mechanisms by which lattice substitutions with impurities lead to size and morphological changes.
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Koolman et al. (1996) studied this question.
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