(1) The uptake of methionine S35 into the histone and two other protein fractions of the Jensen rat sarcoma is not affected in any regular manner by irradiation with 2000 r X rays. (2) It was already known that irradiation with this dose of X rays caused a 50 per cent. inhibition of deoxyribonucleic acid synthesis and in some cases the nucleic acid synthesis (with P32) and the protein turnover (with methionine S35) were investigated in the same animals. It could thus be confirmed that the effects of irradiation on the formation of protein did not correspond with its action on nucleic acid synthesis. At the request of the Editors of the Journal, only an outline of the experimental techniques has been given. The authors will be pleased to supply fuller details to anyone who may be interested.
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Holmes et al. (1952) studied this question.
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